Ultima-CJC1295 2mg

CJC-1295 is a synthetic analogue of GHRH (growth hormone releasing hormone) composed of 30 amino acids. It has demonstrated significant effectiveness in boosting growth hormone and IGF-1 secretion without adversely impacting the pulsatile release of GH.

 

CJC-1295 is frequently paired with Ipamorelin because of its superior specificity as a GHRH. This peptide produces comparable elevations in growth hormone levels but does not influence appetite or increase cortisol, acetylcholine, prolactin, and aldosterone, as seen with other peptides of its category. It has been shown to be very well-tolerated and is ideal for use alongside Ipamorelin.

 

Gland Stimulated: Pituitary

 

Advantages of CJC-1295:

 

Boosted growth hormone and IGF-1 levels without a rise in prolactin

Enhanced body weight and height via increased protein synthesis

Promotion of muscle growth

Improved bone density

Strengthened immune function

Enhanced cognition and memory

Boosted collagen production

Facilitated fat loss

Enhanced cellular repair and regeneration

 

CJC-1295 also supports slow-wave deep sleep, which is essential for optimal muscle growth, memory retention, and overall rejuvenation.

 

Two forms of CJC-1295:

 

GHRH (growth hormone releasing hormone) is made in the hypothalamus. Its pulsatile release stimulates the pituitary gland to secrete GH in a similar pulsatile manner. GHRH has a very short half-life of just a few minutes (half-life refers to the time it takes for half of a substance to be cleared from the blood; a shorter half-life indicates a quicker clearance and less prolonged effect on the body).

 

The active part of GHRH consists of the first 29 amino acids, which are available as a synthetic peptide called Sermorelin. Sermorelin has been modified to extend its half-life to 30 minutes, leading to the development of CJC-1295. Further modification of CJC-1295 includes the addition of DAC (Drug Affinity Complex), which attaches to a blood protein known as albumin, extending its half-life to 8 days. This version is referred to as CJC 1295 + DAC. CJC 1295 can also be compounded in a non-DAC form, mimicking a more typical physiological GH spike each night.

 

The extended half-life due to DAC attachment means that injections are needed only once or twice per week. Nonetheless, this prolonged half-life and relatively stable blood levels provide a continuous stimulus for GH release from the pituitary via the GHRH receptor, which is not physiological. This can result in reduced GH pulse amplitude, leading to diminished GH tissue stimulation.